Immune classification of osteosarcoma
نویسندگان
چکیده
Tumor immune microenvironment has been shown to be important in predicting the tumor progression and outcome of treatments. This work aims identify different patterns osteosarcoma their clinical characteristics. We use latest best performing deconvolution method, CIBERSORTx, obtain relative abundance 22 cells. Then we cluster patients based on estimated study characteristics these clusters, along with relationship between infiltration patients. find that CD8 T cells, NK cells M1 Macrophages have a positive association prognosis, while ?? Mast M0 Dendritic negative prognosis. Accordingly, lowest proportion highest worst among clusters. By grouping similar patterns, are also able suggest treatments specific microenvironment.
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ژورنال
عنوان ژورنال: Mathematical Biosciences and Engineering
سال: 2021
ISSN: ['1547-1063', '1551-0018']
DOI: https://doi.org/10.3934/mbe.2021098